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Unaddressed epithelial-driven inflammation can be challenging in CRSwNP. TEZSPIRE blocks TSLP at a source of inflammation.1-6

The mechanism of action of TEZSPIRE has not been definitively established. Definitive conclusions cannot be made.

CRSwNP=chronic rhinosinusitis with nasal polyps; TSLP=thymic stromal lymphopoietin.

SEE MECHANISM OF DISEASE

TEZSPIRE is contraindicated in patients with a known hypersensitivity to tezepelumab or its excipients. Hypersensitivity reactions, including rash, allergic conjunctivitis, and anaphylaxis can happen. These generally occur within hours of administration but can have a delayed onset. Consider the benefits and risks for the individual patient to determine whether to continue or discontinue treatment with TEZSPIRE.1

Do not abruptly discontinue corticosteroids. Dose reductions, if appropriate, should be gradual and may be associated with withdrawal symptoms and/or unmask previously controlled conditions. Treat patients with pre-existing helminth infections before starting TEZSPIRE. If patients become infected while receiving TEZSPIRE and do not respond to anti-helminth treatment, discontinue TEZSPIRE until the infection resolves. Avoid use of live attenuated vaccines.1

The most common adverse reactions (incidence ≥3%) are1*:

• Asthma: pharyngitis,† arthralgia, and back pain

• CRSwNP: nasopharyngitis, upper respiratory tract infection,‡ epistaxis, pharyngitis,† back pain, influenza, injection site reaction,§ and arthralgia

*This list does not contain all of the possible side effects of TEZSPIRE.

†Pharyngitis (including pharyngitis, pharyngitis bacterial, pharyngitis streptococcal, and viral pharyngitis).1

‡Upper respiratory tract infection (including upper respiratory tract infection and viral upper respiratory tract infection).1

§Injection site reaction (eg, injection site erythema, injection site swelling, and injection site pain).1

CRSwNP=chronic rhinosinusitis with nasal polyps.

SEE SAFETY DATA

In a clinical study of 203 patients receiving TEZSPIRE, patients experienced statistically significant improvements across co-primary endpoints, including NPS (-2.01) and NCS (-0.95) from baseline vs placebo at Week 52.1*† Improvements in NCS were observed as early as the first assessment at Week 2.‡ The LS mean difference in the TEZSPIRE group vs placebo was -0.19 (95% CI: -0.27 to -0.10).7,8

Significant improvements in symptoms,§ such as nasal congestion and loss of smell vs placebo were seen through Week 52.1,8 The LS mean differences in the TEZSPIRE group vs placebo for NCS and LoS score were -0.95 (95% CI: -1.12 to -0.78; P<0.0001) and -1.01 (95% CI: -1.18 to -0.83; P<0.0001), respectively.1,8†II¶

These results are descriptive only and definitive conclusions cannot be made.

Data from the WAYPOINT trial.

*TEZSPIRE baseline NPS score 6.1, LS mean change -2.47; vs placebo baseline NPS score 6.1, LS mean change -0.47; LS mean difference vs placebo -2.01 (95% CI: -2.33 to -1.68); P<0.0001.1,8II#

†TEZSPIRE baseline NCS score 2.59, LS mean change -1.76; vs placebo baseline NCS score 2.55, LS mean change -0.81; LS mean difference vs placebo -0.95 (95% CI: -1.12 to -0.78); P<0.0001.1,8II#

‡Results are descriptive only. Definitive conclusions cannot be made.

§NPSD TSS included the assessment of 8 symptoms: nasal blockage, nasal congestion, runny nose, postnasal drip, headache, facial pain, facial pressure, and difficulty with sense of smell.9

||All P values are reported as unadjusted.8

TEZSPIRE baseline LoS 2.9, LS mean change -1.29; vs placebo baseline LoS 2.8, LS mean change -0.28; LS mean difference vs placebo -1.01 (95% CI: -1.18 to -0.83); P<0.0001.8II#

#Denotes statistically significant level under multiple testing strategy.8

CI=confidence interval; LS=least-squares; LoS=loss of smell; NCS=nasal congestion score; NPSD=Nasal Polyposis Symptom Diary; TSS=total symptom score.

EXPLORE EFFICACY

In a clinical study of 203 patients receiving TEZSPIRE, patients experienced meaningful improvement in how they felt as shown by a 45-point reduction in the SNOT-22 total score from baseline at Week 52. The SNOT-22 domains include nasal, ear/facial, sleep, function, and emotion.1,8,10*†

The study was not designed to measure the impact of treatment on individual components. Therefore, improvement in the total aggregate SNOT-22 total score does not necessarily correlate with a positive effect on each individual item or domain.10,11

SNOT-22 total scores should be interpreted in the context that they may include irrelevant items or items not well understood by patients with CRSwNP. There may also be redundancies in SNOT-22 items and WAYPOINT endpoints.

Data from the WAYPOINT trial.

*TEZSPIRE baseline 68.2, LS mean change -45.23; vs placebo baseline 69.2, LS mean change -18.89; LS mean difference vs placebo -26.54 (95% CI: -31.58 to -21.50).8

†Total scores range from 0-110, with higher scores indicating poorer outcomes.11

CI=confidence interval; CRSwNP=chronic rhinosinusitis with nasal polyps; LS=least-squares; QoL=quality of life; SNOT-22=Sino-Nasal Outcome Test-22.

EXPLORE EFFICACY

In a clinical study of 203 patients receiving TEZSPIRE, there was a 92% reduction in the need for systemic corticosteroid use and/or surgery over 52 weeks vs placebo (HR: 0.08, 95% CI: 0.03-0.17; P<0.0001).1,12*†‡ In this study, 71% of patients had undergone previous surgery.1 TEZSPIRE reduced the need for surgery by 98% over 52 weeks vs placebo (HR: 0.02, 95% CI: 0.00-0.09; P<0.0001).1,12*†§ With TEZSPIRE, there was an 88% reduction in need for SCS use over 52 weeks vs placebo (HR: 0.12, 95% CI: 0.04-0.27; P<0.0001).1,12*†II

Data from the WAYPOINT trial.

*All P values are reported as unadjusted.12

†Denotes statistically significant level under multiple testing strategy.8

‡Number of events (Kaplan-Meier estimate): TEZSPIRE 6 (5.7%) vs placebo 60 (30.6%).12

§Number of events (Kaplan-Meier estimate): TEZSPIRE 1 (0.5%) vs placebo 42 (22.1%).12

IINumber of events (Kaplan-Meier estimate): TEZSPIRE 5 (5.2%) vs placebo 36 (18.3%).12

CI=confidence interval; HR=hazard ratio; SCS=systemic corticosteroid

EXPLORE EFFICACY

In two severe asthma trials, TEZSPIRE showed significant exacerbation reductions vs placebo (PATHWAY 71%, NAVIGATOR 56%, P<0.001; primary endpoint) and a 230 mL improvement in lung function vs baseline (NAVIGATOR; secondary endpoint).1*

In a post hoc analysis of patients with both severe asthma and CRSwNP, reductions in asthma exacerbations were observed. In this 52-week analysis, there was an 85% reduction in exacerbations vs placebo and a 95% reduction in exacerbations requiring hospitalizations, urgent care, or ED visits vs placebo1,9,13,14†‡

Results are descriptive only. Definitive conclusions cannot be made.

Data from the NAVIGATOR trial.

*PATHWAY AAER: TEZSPIRE + SOC 0.20 (n=137) vs placebo + SOC 0.72 (n=138); RR: 0.29 (95% Cl: 0.16-0.51); NAVIGATOR AAER: TEZSPIRE + SOC 0.93 (n=528) vs placebo + SOC 2.10 (n=531); RR: 0.44 (95% CI: 0.37-0.53).1

†Post hoc analysis of NAVIGATOR data. AAER TEZSPIRE + SOC (n=62) 0.43 (95% CI: 0.26-0.71) vs placebo + SOC (n=56) 2.87 (95% CI: 1.98-4.17); RR: 0.15 (95% CI: 0.08-0.28).13

‡Post hoc analysis of NAVIGATOR data. AAER TEZSPIRE + SOC (n=62) 0.02 (95% CI: 0.00-0.14) vs placebo + SOC (n=56) 0.30 (95% CI: 0.11-0.82); RR: 0.05 (95% CI: 0.01-0.56).14

AAER=annualized asthma exacerbation rate; CI=confidence interval; CRSwNP=chronic rhinosinusitis with nasal polyps; ED=emergency department; RR=rate ratio; SOC=standard of care.

EXPLORE EFFICACY

The most common adverse reactions (incidence ≥3%) are1*:

• Asthma: pharyngitis,† arthralgia, and back pain

• CRSwNP: nasopharyngitis, upper respiratory tract infection,‡ epistaxis, pharyngitis,† back pain, influenza, injection site reaction,§ and arthralgia

*This list does not contain all of the possible side effects of TEZSPIRE.

†Pharyngitis (including pharyngitis, pharyngitis bacterial, pharyngitis streptococcal, and viral pharyngitis).1

‡Upper respiratory tract infection (including upper respiratory tract infection and viral upper respiratory tract infection).1

§Injection site reaction (eg, injection site erythema, injection site swelling, and injection site pain).1

CRSwNP=chronic rhinosinusitis with nasal polyps.

SEE SAFETY DATA

TEZSPIRE is administered subcutaneously every 4 weeks from either a pre-filled syringe or a pre-filled pen.

The TEZSPIRE pre-filled syringe is administered by a healthcare provider, and the pre-filled pen can be administered by patients/caregivers or healthcare providers.1

LEARN MORE ABOUT DOSING & ADMINISTRATION

No. There’s a standard recommended dosage for all patients1:

  • 210 mg administered subcutaneously every 4 weeks

There is no loading dose, variation in dosing schedule, or dose adjustments based on weight or biomarker level.1

LEARN MORE ABOUT DOSING & ADMINISTRATION

If a dose is missed, administer the dose as soon as possible. After, your patient can continue (resume) dosing on the usual day of administration. If the next dose is already due, then administer as planned.1

LEARN MORE ABOUT DOSING & ADMINISTRATION

Instructions for use will vary based on your preferred method of administration–pre-filled syringe or pre-filled pen. Find both in the Instructions for Use.

TEZSPIRE Together offers a variety of support to help you and your patients get started and continue throughout their treatment journey.

Our co-pay program helps eligible commercially insured patients reduce out-of-pocket costs. Patients may pay as little as $0 for each dose of medication.* The program also covers up to $100 per month of patient costs for in-office administration.†

TEZSPIRE Together offers an online healthcare provider portal to help you with electronic benefits verifications, prior authorizations, and appeals support.

*For commercially insured patients only. Eligibility criteria and program maximums apply. See TEZSPIRE.com for full program details.

†Patients who are residents of Massachusetts or Rhode Island are not eligible for injection administration support.

LEARN MORE ABOUT SUPPORT & RESOURCES

TEZSPIRE Together offers a variety of resources throughout the treatment journey, including help with:

  • Electronic benefits verifications
  • Prior authorizations
  • Appeals

Our co-pay program helps eligible commercially insured patients reduce out-of-pocket costs. Patients may pay as little as $0 for each dose of medication.* The program also covers up to $100 per month of patient costs for in-office administration.†

*For commercially insured patients only. Eligibility criteria and program maximums apply. See TEZSPIRE.com for full program details.

†Patients who are residents of Massachusetts or Rhode Island are not eligible for injection administration support.

LEARN MORE ABOUT SUPPORT & RESOURCES

There are 2 ways to enroll:

Portal Registration

Online

Via the TEZSPIRE Together HCP Portal

Fax Registration

Fax

Download and print the enrollment form, then fax the completed form to 1-888-388-6016

HELP GET PATIENTS STARTED

Important Safety Information

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CONTRAINDICATIONS

Known hypersensitivity to tezepelumab-ekko or excipients.

WARNINGS AND PRECAUTIONS

Hypersensitivity Reactions

Hypersensitivity reactions were observed in the clinical trials (eg, rash and allergic conjunctivitis) following the administration of TEZSPIRE. Postmarketing cases of anaphylaxis have been reported. These reactions can occur within hours of administration, but in some instances have a delayed onset (i.e., days). In the event of a hypersensitivity reaction, consider the benefits and risks for the individual patient to determine whether to continue or discontinue treatment with TEZSPIRE.

Acute Asthma Symptoms or Deteriorating Disease

TEZSPIRE should not be used to treat acute asthma symptoms, acute exacerbations, acute bronchospasm, or status asthmaticus.

Abrupt Reduction of Corticosteroid Dosage

Do not discontinue systemic or inhaled corticosteroids abruptly upon initiation of therapy with TEZSPIRE. Reductions in corticosteroid dose, if appropriate, should be gradual and performed under the direct supervision of a physician. Reduction in corticosteroid dose may be associated with systemic withdrawal symptoms and/or unmask conditions previously suppressed by systemic corticosteroid therapy.

Parasitic (Helminth) Infection

It is unknown if TEZSPIRE will influence a patient’s response against helminth infections. Treat patients with pre-existing helminth infections before initiating therapy with TEZSPIRE. If patients become infected while receiving TEZSPIRE and do not respond to anti-helminth treatment, discontinue TEZSPIRE until infection resolves.

Live Attenuated Vaccines

The concomitant use of TEZSPIRE and live attenuated vaccines has not been evaluated. The use of live attenuated vaccines should be avoided in patients receiving TEZSPIRE.

ADVERSE REACTIONS

The most common adverse reactions (incidence ≥ 3%) are:

  • Asthma: pharyngitis, arthralgia, and back pain.
  • Chronic rhinosinusitis with nasal polyps: nasopharyngitis, upper respiratory tract infection, epistaxis, pharyngitis, back pain, influenza, injection site reaction and arthralgia

USE IN SPECIFIC POPULATIONS

There are no available data on TEZSPIRE use in pregnant women to evaluate for any drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes. Placental transfer of monoclonal antibodies such as tezepelumab-ekko is greater during the third trimester of pregnancy; therefore, potential effects on a fetus are likely to be greater during the third trimester of pregnancy.

INDICATION

TEZSPIRE is indicated for:

  • the add-on maintenance treatment of adult and pediatric patients aged 12 years and older with severe asthma. TEZSPIRE is not indicated for the relief of acute bronchospasm or status asthmaticus
  • the add-on maintenance treatment of adult and pediatric patients aged 12 years and older with inadequately controlled chronic rhinosinusitis with nasal polyps (CRSwNP)

Please see full Prescribing Information, including
Patient Information and Instructions for Use.

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Important Safety Information

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References: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 2.  Menzies-Gow A, Corren J, Bourdin A, et al. Appendix to: Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19)(suppl):1-60.

Reference: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025.

References: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 2. Gauvreau GM, Sehmi R, Ambrose CS, et al. Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma. Expert Opin Ther Targets. 2020;24(8):777-792. 3. Menzies-Gow A, Wechsler ME, Brightling CE. Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option? Respir Res. 2020;21(1):268. 4. Menzies-Gow A, Corren J, Bourdin A, et al. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19):1800-1809.

References: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 2. Menzies-Gow A, Wechsler ME, Brightling CE. Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option? Respir Res. 2020;21(1):268. 3. Gauvreau GM, Sehmi R, Ambrose CS, et al. Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma. Expert Opin Ther Targets. 2020;24(8):777-792. 4. Panettieri R Jr, Lugogo N, Corren J, Ambrose CS. Tezepelumab for severe asthma: one drug targeting multiple disease pathways and patient types. J Asthma Allergy. 2024;17:219-236. 5. Corren J, Menzies-Gow A, Chupp G, et al. Efficacy of tezepelumab in severe, uncontrolled asthma: pooled analysis of the PATHWAY and NAVIGATOR clinical trials. Am J Respir Crit Care Med. 2023;208(1):13-24. 6. Data on File. US-105253, AstraZeneca Pharmaceuticals LP. 7. Data on File. US-98796, AstraZeneca Pharmaceuticals LP.

Reference: 1. Data on File. US-105253, AstraZeneca Pharmaceuticals LP.

References: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 2. Panettieri R Jr, Lugogo N, Corren J, Ambrose CS. Tezepelumab for severe asthma: one drug targeting multiple disease pathways and patient types. J Asthma Allergy. 2024;17:219-236. 3. Corren J, Menzies-Gow A, Chupp G, et al. Efficacy of tezepelumab in severe, uncontrolled asthma: pooled analysis of the PATHWAY and NAVIGATOR clinical trials. Am J Respir Crit Care Med. 2023;208(1):13-24. 4. Data on File. US-91518, AstraZeneca Pharmaceuticals LP.

Reference: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025.

References: 1. Price D, Dale P, Elder E, Chapman KR. Types, frequency and impact of asthma triggers on patients’ lives: a quantitative study in five European countries. J Asthma. 2014;51(2):127-135. 2. Gautier C, Charpin D. Environmental triggers and avoidance in the management of asthma. J Asthma Allergy. 2017;10:47-56. 3. Chipps BE, Soong W, Panettieri RA Jr, et al. Number of patient-reported asthma triggers predicts uncontrolled disease among specialist-treated patients with severe asthma. Ann Allergy Asthma Immunol. 2023;130(6):784-790.e5. 4. Porsbjerg CM, Sverrild A, Lloyd CM, et al. Anti-alarmins in asthma: targeting the airway epithelium with next-generation biologics. Eur Respir J. 2020;56(5):2000260. 5. Menzies-Gow A, Wechsler ME, Brightling CE. Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option? Respir Res. 2020;21(1):268. 6. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 7. Gauvreau GM, Sehmi R, Ambrose CS, Griffiths JM. Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma. Expert Opin Ther Targets. 2020;24(8):777-792. 8. Panettieri R Jr, Lugogo N, Corren J, Ambrose CS. Tezepelumab for severe asthma: one drug targeting multiple disease pathways and patient types. J Asthma Allergy. 2024;17:219-236.

References: 1. Data on File. REF-134673, AstraZeneca Pharmaceuticals LP. 2. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 3. Menzies-Gow A, Corren J, Bourdin A, et al. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19):1800-1809. 4. Data on File. REF-134414, AstraZeneca Pharmaceuticals LP. 5. Laidlaw TM, Menzies-Gow A, Caveney S, et al. Tezepelumab efficacy in patients with severe, uncontrolled asthma with comorbid nasal polyps in NAVIGATOR. J Asthma Allergy. 2023;16:915-932. 6. Data on File. REF-263922, AstraZeneca Pharmaceuticals LP. 7. Menzies-Gow A, Corren J, Bourdin A, et al. Appendix to: Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(suppl):1-60.

References: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 2. Gauvreau GM, Sehmi R, Ambrose CS, et al. Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma. Expert Opin Ther Targets. 2020;24(8):777-792. 3. Menzies-Gow A, Wechsler ME, Brightling CE. Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option? Respir Res. 2020;21(1):268. 4. Panettieri R Jr, Lugogo N, Corren J, Ambrose CS. Tezepelumab for severe asthma: one drug targeting multiple disease pathways and patient types. J Asthma Allergy. 2024;17:219-236. 5. Corren J, Menzies-Gow A, Chupp G, et al. Efficacy of tezepelumab in severe, uncontrolled asthma: pooled analysis of the PATHWAY and NAVIGATOR clinical trials. Am J Respir Crit Care Med. 2023;208(1):13-24. 6. Menzies-Gow A, Corren J, Bourdin A, et al. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19):1800-1809. 7. Menzies-Gow A, Corren J, Bourdin A, et al. Appendix to: Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19):1800-1809. 8. Dunican EM, Elicker BM, Gierada DS, et al. Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest. 2018;128(3):997-1009. 9. Diver S, Khalfaoui L, Emson C, et al; CASCADE study investigators. Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial. Lancet Respir Med. 2021;9(11):1299-1312. 10. Nordenmark LH, Hellqvist Å, Emson C, et al. Tezepelumab and mucus plugs in patients with moderate-to-severe asthma. NEJM Evid. 2023;2(10):1-10. 11. Data on File. REF-176078, AstraZeneca Pharmaceuticals LP. 12. Data on File. REF-188753, AstraZeneca Pharmaceuticals LP. 13. Data on File. REF-148129, AstraZeneca Pharmaceuticals LP.

References: 1. Panettieri R Jr, Lugogo N, Corren J, Ambrose CS. Tezepelumab for severe asthma: one drug targeting multiple disease pathways and patient types. J Asthma Allergy. 2024;17:219-236. 2. Chipps BE, Soong W, Panettieri RA Jr, et al. Number of patient-reported asthma triggers predicts uncontrolled disease among specialist-treated patients with severe asthma. Ann Allergy Asthma Immunol. 2023;130(6):784-790.e5. 3. Menzies-Gow A, Wechsler ME, Brightling CE. Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option? Respir Res. 2020;21(1):268. 4. Denton E, Price DB, Tran TN, et al. Cluster analysis of inflammatory biomarker expression in the International Severe Asthma Registry. J Allergy Clin Immunol Pract. 2021;9(7):2680-2688.e7. 5. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 6. Data on File. REF-204597, AstraZeneca Pharmaceuticals LP. 7. Data on File. REF-181622, AstraZeneca Pharmaceuticals LP. 8. Data on File. REF-134414, AstraZeneca Pharmaceuticals LP. 9. Gautier C, Charpin D. Environmental triggers and avoidance in the management of asthma. J Asthma Allergy. 2017;10:47-56. 10. Data on File. REF-224439, AstraZeneca Pharmaceuticals LP. 11. Corren J, Karpefors M, Hellqvist Å, Parnes JR, Colice G. Tezepelumab reduces exacerbations across all seasons in patients with severe, uncontrolled asthma: a post hoc analysis of the PATHWAY phase 2b study. J Asthma Allergy. 2021;14:1-11.

References: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 2. Data on File. REF-181622, AstraZeneca Pharmaceuticals LP.

References: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 2. Data on File. REF-204597, AstraZeneca Pharmaceuticals LP.

References: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 2. Data on File. REF-204597, AstraZeneca Pharmaceuticals LP.

References: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 2. Corren J, Parnes JR, Wang L, et al. Tezepelumab in adults with uncontrolled asthma. N Engl J Med. 2017;377(10):936-946. 3. Menzies-Gow A, Corren J, Bourdin A, et al. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19):1800-1809. 4. Corren J, Parnes JR, Wang L, et al. Appendix to: Tezepelumab in adults with uncontrolled asthma. N Engl J Med. 2017;377(suppl):1-54. 5. Menzies-Gow A, Corren J, Bourdin A, et al. Appendix to: Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(suppl):1-60. 6. Diver S, Khalfaoui L, Emson C, et al; CASCADE study investigators. Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial. Lancet Respir Med. 2021;9(11):1299-1312. 7. Data on File. REF-134673, AstraZeneca Pharmaceuticals LP.

References: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 2. Data on File. REF-204597, AstraZeneca Pharmaceuticals LP. 3. Data on File. REF-181622, AstraZeneca Pharmaceuticals LP.

References: 1. Denton E, Price DB, Tran TN, et al. Cluster analysis of inflammatory biomarker expression in the International Severe Asthma Registry. J Allergy Clin Immunol Pract. 2021;9(7):2680-2688.e7. 2. Chipps BE, Soong W, Panettieri RA Jr, et al. Number of patient-reported asthma triggers predicts uncontrolled disease among specialist-treated patients with severe asthma. Ann Allergy Asthma Immunol. 2023;130(6):784-790.e5. 3. Panettieri R Jr, Lugogo N, Corren J, Ambrose CS. Tezepelumab for severe asthma: one drug targeting multiple disease pathways and patient types. J Asthma Allergy. 2024;17:219-236. 4. Menzies-Gow A, Wechsler ME, Brightling CE. Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option? Respir Res. 2020;21(1):268. 5. Gauvreau GM, Sehmi R, Ambrose CS, Griffiths JM. Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma. Expert Opin Ther Targets. 2020;24(8):777-792. 6. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 7. Diver S, Khalfaoui L, Emson C, et al; CASCADE study investigators. Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial. Lancet Respir Med. 2021;9(11):1299-1312. 8. Data on File. REF-148129, AstraZeneca Pharmaceuticals LP. 9. Data on File. REF-204597, AstraZeneca Pharmaceuticals LP. 10. Data on File. REF-181622, AstraZeneca Pharmaceuticals LP. 11. Data on File. REF-134414, AstraZeneca Pharmaceuticals LP. 12. Menzies-Gow A, Corren J, Bourdin A, et al. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19):1800-1809. 13. Data on File. REF-224439, AstraZeneca Pharmaceuticals LP. 14. Corren J, Karpefors M, Hellqvist Å, Parnes JR, Colice G. Tezepelumab reduces exacerbations across all seasons in patients with severe, uncontrolled asthma: a post hoc analysis of the PATHWAY phase 2b study. J Asthma Allergy. 2021;14:1-11. 15. Data on File. US-98281, AstraZeneca Pharmaceuticals LP.

References: 1. Porsbjerg CM, Sverrild A, Lloyd CM, et al. Anti-alarmins in asthma: targeting the airway epithelium with next-generation biologics. Eur Respir J. 2020;56(5):2000260. 2. Menzies-Gow A, Wechsler ME, Brightling CE. Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option? Respir Res. 2020;21(1):268. 3. Panettieri R Jr, Lugogo N, Corren J, Ambrose CS. Tezepelumab for severe asthma: one drug targeting multiple disease pathways and patient types. J Asthma Allergy. 2024;17:219-236. 4. Corren J, Menzies-Gow A, Chupp G, et al. Efficacy of tezepelumab in severe, uncontrolled asthma: pooled analysis of the PATHWAY and NAVIGATOR clinical trials. Am J Respir Crit Care Med. 2023;208(1):13-24. 5. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 6. Brace yourselves: the biggest week for asthma attacks is coming. Asthma and Allergy Foundation of America. Published August 25, 2022. Accessed August 5, 2025. https://community.aafa.org/blog/September-Asthma-Peak-brace-yourselves-the-biggest-week-for-asthma-attacks-is-coming. 7. Protect your child against the September epidemic. National Jewish Health. Accessed August 5, 2025. https://www.nationaljewish.org/conditions/health-information/multimedia/living-with-asthma/protect-your-child-against-the-september-epidemic. 8. Sheehan WJ, Patel SJ, Margolis RH, et al. Pediatric asthma exacerbations during the COVID-19 pandemic: absence of the typical fall seasonal spike in Washington, DC. J Allergy Clin Immunol Pract. 2021;9(5):2073-2076. 9. Gautier C, Charpin D. Environmental triggers and avoidance in the management of asthma. J Asthma Allergy. 2017;10:47-56. 10. Chipps BE, Soong W, Panettieri RA Jr, et al. Number of patient-reported asthma triggers predicts uncontrolled disease among specialist-treated patients with severe asthma. Ann Allergy Asthma Immunol. 2023;130(6):784-790.e5.

References: 1. van der Veen J, Seys SF, Timmermans M, et al. Real-life study showing uncontrolled rhinosinusitis after sinus surgery in a tertiary referral centre. Allergy. 2017;72(2):282-290. 2. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 3. Menzies-Gow A, Wechsler ME, Brightling CE. Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option? Respir Res. 2020;21(1):268.

References: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 2. Menzies-Gow A, Wechsler ME, Brightling CE. Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option? Respir Res. 2020;21(1):268. 3. Data on File. US-98796, AstraZeneca Pharmaceuticals LP.

References: 1. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; October 2025. 2. Data on File. REF-292218, AstraZeneca Pharmaceuticals LP. 3. Pfaar O, Han JK, Desrosiers M, et al. Onset of action of tezepelumab in adults with severe, uncontrolled chronic rhinosinusitis with nasal polyps in the phase 3 WAYPOINT study. Presented at: European Rhinologic Society (ERS) 2025 Congress; June 22-25, 2025; Budapest, Hungary. 4. Lipworth BJ, Han JK, Desrosiers M, et al. Tezepelumab in adults with severe chronic rhinosinusitis with nasal polyps [Appendix]. N Engl J Med. 2025;392(12):1178-1188. 5. Lipworth BJ, Han JK, Desrosiers M, et al. Tezepelumab in adults with severe chronic rhinosinusitis with nasal polyps. N Engl J Med. 2025;392(12):1178-1188. 6. Chowdhury NI, Mace JC, Bodner TE, et al. Investigating the minimal clinically important difference for SNOT-22 symptom domains in surgically managed chronic rhinosinusitis. Int Forum Allergy Rhinol. 2017;7(12):1149-1155. 7. Data on File. REF-287771, AstraZeneca Pharmaceuticals LP. 8. Data on File. WAYPOINT Clinical study report. Tezepelumab D5242C00001; January 23, 2025.

References: 1. Kato A, Schleimer RP, Bleier BS. Mechanisms and pathogenesis of chronic rhinosinusitis. J Allergy Clin Immunol. 2022;149(5):1491-1503. 2. Peters A, Zhao X, Near AM, et al. Real-world outcomes following biologic initiation in US patients with chronic rhinosinusitis with nasal polyps. Adv Ther. 2025;42(4):1783-1799. 3. Bachert C, Zhang N, Cavaliere C, Weiping W, Gevaert E, Krysko O. Biologics for chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2020;145(3):725-739. 4. Menzies-Gow A, Wechsler ME, Brightling CE. Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option? Respir Res. 2020;21(1):268. 5. Gauvreau GM, Sehmi R, Ambrose CS, Griffiths JM. Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma. Expert Opin Ther Targets. 2020;24(8):777-792. 6. Ha J-G, Cho H-J. Unraveling the role of epithelial cells in the development of chronic rhinosinusitis. Int J Mol Sci. 2023;24(18):14229. 7. Chipps BE, Soong W, Panettieri RA Jr, et al. Number of patient-reported asthma triggers predicts uncontrolled disease among specialist-treated patients with severe asthma. Ann Allergy Asthma Immunol. 2023;130(6):784-790.e5. 8. Denton E, Price DB, Tran TN, et al. Cluster analysis of inflammatory biomarker expression in the International Severe Asthma Registry. J Allergy Clin Immunol Pract. 2021;9(7):2680-2688.e7. 9. Gautier C, Charpin D. Environmental triggers and avoidance in the management of asthma. J Asthma Allergy. 2017;10:47-56.

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